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教師陳皇州

教師：陳皇州 Kelvin H.-C. Chen    

職稱：教授  兼  國際事務長 暨 國際學院院長

Professor 

Dean of Office of International Affairs

Dean of International College

 

主要研究方向：

蛋白質純化製備、金屬毒性分析、無機金屬催化

Protein Purification and Preparation; Metal Toxicity Analysis; Inorganic Metal Catalysis

 

聯絡資訊：

Tel: 08-7663800 ext. 33254

E-mail: kelvin@mail.nptu.edu.tw

 

最高學歷：

國立清華大學化學博士

Ph.D., Chemistry, National Tsing Hua University

 

經歷：

國立屏東大學應用化學系 教授

國立屏東大學應用化學系 系主任

國立屏東大學教務處課務組 組長

國立屏東大學應用化學系 副教授

國立屏東教育大學研發處學術發展組 組長

國立屏東教育大學化學生物系 助理教授

美國俄亥俄州立大學生物化學系 博士後研究學者

中央研究院 特約博士後研究學者

 

近年執行計畫：

1.微粒體型甲烷單加氧酵素親水性次單元PmoB重組蛋白銅金屬重建及其蛋白質交互作用之研究（科技部專題研究計畫，計畫主持人，2019-2020）

2.嗜甲烷菌中全活性微粒體甲烷單氧化酵素與甲醇去氫酶的純化、生化活性鑑定及其蛋白質複合物共結晶的製備（中央研究院主題研究計畫，子計畫主持人，2019-2021）

3.嗜甲烷菌中氧氣攜帶蛋白hemerythrin與微粒體型甲烷單氧化酵素交互作用之研究（科技部專題研究計畫，計畫主持人，2017-2019）

4.以同步輻射X光吸收光譜探討Bateriohemerythrin的氧氣結合功能及其反應機制（屏東大學跨國研究補助試辦計畫，計畫主持人，2017)

近年代表著作：

  1. Vladimir Mironov, Irina A Shchugoreva, Polina V Artyushenko, Dmitry Morozov, Nicola Borbone, Giorgia Oliviero, Tatiana N Zamay, Roman V Moryachkov, Olga S Kolovskaya, Kirill A Lukyanenko, Yangling Song, Iuliia A Merkuleva, Vladimir N Zabluda, Georgy Peters, Lyudmila S Koroleva, Dmitry V Veprintsev, Yury E Glazyrin, Ekaterina A Volosnikova, Svetlana V Belenkaya, Tatiana I Esina, Anastasiya A Isaeva, Valentina S Nesmeyanova, Daniil V Shanshin, Anna N Berlina, Nadezhda S Komova, Valery A Svetlichnyi, Vladimir N Silnikov, Dmitriy N Shcherbakov, Galina S Zamay, Sergey S Zamay, Tatyana Smolyarova , Elena P Tikhonova, Kelvin H-C Chen, U-Ser Jeng, Gerolama Condorelli, Vittorio de Franciscis, Gerrit Groenhof, Chaoyong Yang , Alexander A Moskovsky, Dmitri G Fedorov, Felix N Tomilin, Weihong Tan, Yuri Alexeev, Maxim V Berezovski, Anna S Kichkailo. Structure and Interaction Based Design of Anti-SARS-CoV-2 Aptamers. Chemistry-A European Journal. (2022) doi: 10.1002/chem.202104481.
  2. Gilbert Audira, Jiann-Shing Lee, Petrus Siregar, Nemi Malhotra, Marri Jmelou M. Rolden, Jong-Chin Huang, Kelvin H.-C. Chen, Hua-Shu Hsu, Yuchun Hsu, Tzong-Rong Ger and Chung-Der Hsiao*. Comparison of the Chronic Toxicities of Graphene and Graphene Oxide Toward Adult Zebrafish by Using Biochemical and Phenomic Approaches. (2021) Environmental Pollution, 278, 116907 (SCI; Impact Factor:6.792).
  3. Sunney I. Chan*, Phimonphan Chuankhayan, Pavan Kumar Reddy Nareddy, I-Kuen Tsai, Yi-Fang Tsai, Kelvin H.-C. Chen, Steve S.-F. Yu*, Chun-Jung Chen*. Mechanism of Pyrroloquinoline Quinone-Dependent Hydride Transfer Chemistry from Spectroscopic and High-Resolution X‑ray Structural Studies of the Methanol Dehydrogenase from Methylococcus capsulatus (Bath). (2021) J. Am. Chem. Soc., 143, 9, 3359-3372. https://doi.org/10.1021/jacs.0c11414. (SCI; Impact Factor: 14.612).
  4. Chung-Der Hsiao, Hsin-Hui Wu, Nemi Malhotra, Yen-Ching Liu, Ying-Hsuan Wu, Yu‐Nung Lin, Ferry Saputra, Fiorency Santoso and Kelvin H.-C. Chen*. Expression and Purification of Recombinant GHK Tripeptides Are Able to Protect against Acute Cardiotoxicity from Exposure to Waterborne-Copper in Zebrafish. (2020) Biomolecules, 10, 1202, 1-17. doi:10.3390/biom10091202 (SCI; Impact Factor: 4.879).
  5. Nemi Malhotra, Tzong-Rong Ger, Boontida Uapipatanakul, Jong-Chin Huang, Kelvin H.-C. Chen*, and Chung-Der Hsiao*. Review of Copper and Copper Nanoparticle Toxicity to Fish. (2020) Nanomaterials, 10, 1126, 1-28. (SCI; Impact Factor: 5.076).
  6. Tsun-Ren Chen*, Yi-Sheng Lin, Yu-Xiang Wang, Wen-Jen Lee, Kelvin H.-C. Chen and Jhy-Der Chen. Graphene oxide–iridium nanocatalyst for the transformation of benzylic alcohols into carbonyl compounds (2020) RSC Advances, 10, 4436-4450. (SCI; Impact Factor: 3.049)
  7. Tsun-Ren Chen*, Yu-Xiang Wang, Wen-Jen Lee, Kelvin H.-C. Chen and Jhy-Der Chen. A reduced graphene oxide-supported iridium nanocatalyst for selective transformation of alcohols into carbonyl compounds via a green process. (2020) Nanotechnology, 31, 285705-285715. (SCI; Impact Factor: 3.399)
  8. Kelvin H.-C. Chen, Hui-Chuan Wei, Ai-Tzu Li, Wei-Ni Wang and Yu-Hsien Liao*. The Supreme-core on Multicriteria Fuzzy Games. (2020) Journal of Intelligent & Fuzzy Systems, 38, 2, 1753-1760. (SCI; Impact Factor: 1.637) 
  9. Yu-Jhang Lu, Mu-Cheng Hung, Brian T.-A. Chang, Tsu-Lin Lee, Zhi-Han Lin, I-Kuen Tsai, Yao-Sheng Chen, Chin-Shuo Chang, Yi-Fang Tsai, Kelvin H.-C. Chen, Sunney I. Chan and Steve S.-F. Yu*. The PmoB subunit of particulate methane monooxygenase (pMMO) in Methylococcus capsulatus (Bath): The CuI sponge and its function (2019) J. Inorg. Biochem., 196, Article 110691. (SCI; Impact Factor: 3.224) 
  10. Kenneth Y.-T. Lim, Kelvin H.-C. Chen, Sheau-Wen Lin. Jong-Chin Huang, Kristal S.-E. Ng, Joel J.- L. Ng, Yifei Wang, Nicholas Woong. Representations of Novice Conceptions with Learner-Generated Augmentation: A Framework for Curriculum Design with Augmented Reality. (2018) Journal of Virtual World Research 11, 3, Pedagogy (Part 1).
  11. Tsun-Ren Chen*, Pei-Chun Liu, Hsiu-Pen Lee, Fang-Siou Wu, Kelvin H.-C. Chen. Cyclometalated Iridium (III) complexes with ligand effect on catalytic carbon hydrogen bond activation of toluene in high performance. (2017) Euro. J. Inorg. Chem. 13, 2023-2031. (SCI; Impact Factor: 2.686)
  12. Yi-Ting Chen, Kelvin H.-C. Chen, Mituhiro Fukuda*. DFT study for evaluation of the interaction of coordinated molecule to Fe(III) in various iron(III) chloride complexes. (2016) J. Comp. Chem., Japan.
  13. Tsun-Ren Chen*, Fang-Siou Wu, Hsiu-Pen Lee, Kelvin H.-C. Chen.  Diiridium bimetallic complexes function as a redox switch to directly split carbonate into carbon monoxide and oxygen. (2016) J. Am. Chem. Soc., 138, 3643-3646. (SCI; Impact Factor: 12.113)
  14. 李賢哲; 陳皇州; 陳存仁; 林曉雯; 李文仁; 許華書; 賴岦俊。動手做科學教育中心之設計與實踐。(2016) 科學教育月刊, 391, 40-52.
  15. Kelvin H.-C. Chen*, Phimonphan Chuankhayan, Hsin-Hui Wu, Chun-Jung Chen*, Mitsuhiro Fukuda, Steve S.-F. Yu, Sunney I. Chan. The bacteriohemerythrin from Methylococcus capsulatus (Bath): Crystal structures reveal that Leu114 regulates a water tunnel. (2015) J. Inorg. Biochem., 150, 81-89. (SCI; Impact Factor: 3.444)
  16. Kelvin H.-C. Chen*, Hsin-Hui Wu, Si-Fu Ke, Ya-Ting Rao, Chia-Ming Tu, Yu-Ping Chen, Kuo-Hsuan Kuei, Ying-Siao Chen, Vincent C.-C. Wang, Wei-Chun Kao, Sunney I. Chan. Bacteriohemerythrin bolsters the activity of the particulate methane monooxygenase (pMMO) in Methylococcus capsulatus (Bath). (2012) J. Inorg. Biochem., 111, 10-17. (SCI; Impact Factor: 3.317).

主要教學科目：

普通生物學、微生物學、蛋白質化學、高等生物化學