教師樊琳

教師：樊琳教授

主要研究方向：蛋白質結構與功能之探討

Tel：08-766-3800 ext.：33255

E-mail：lfarh@mail.nptu.edu.tw

近五年執行計畫：

國科會計畫：探討IIA型DNA拓撲異構酶各功能區參與之交互作用及其在酵素功能上的意義、生物資訊融入生命科學相關學科之教學—以專題為主導的教學策略研究與評量工具開發、以X-光結晶學探討二種生物巨分子之搬運機組:第IIA型DNA拓撲異構酶與第二型蛋白分泌機組、

代表著作：

Mutations in the X-linked Intellectual Disability Gene, zDHHC9, Alter Autopalmitoylation Activity by Distinct Mechanisms, David A. Mitchell, Laura D. Hamel, Krishna D. Reddy, Lynn Farh, Logan M. Rettew, Phillip R. Sanchez and Robert J. Deschenes, 2014; The Journal of Biological Chemistry 289, 18582-18592.
Physalin B from Physalis angulata triggers the NOXA-related apoptosis pathway of human melanoma A375 cells, Chia-Chun Hsu, Yang-Chang Wu, Lynn Farh, Ying-Chi Du, Wei-Kung Tseng, Chau-Chung Wu, Fang-RongChang; Food and Chemical Toxicology, Vol 50, Issues 3–4, March–April 2012, Pages 619-624
Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide, Chyuan-Chuan Wu, Tsai-Kun Li, Lynn Farh, Li-Ying Lin, Te-Sheng Lin, Yu-Jen Yu, Tien-Jui Yen, Chia-Wang Chiang, Nei-Li Chan; Science 22 Jul 2011: Vol. 333, Issue 6041, pp. 459-462
Hsieh TJ, Yen TJ, Lin TS, Chang HT, Huang SY, Hsu CH, Farh L, Chan NL.(2010) Twisting of the DNA-binding surface by a {beta}-strand-bearing proline modulates DNA gyrase activity. Nucleic Acids Res.(SCI)
Swarthout JT, Lobo S, Farh L, Croke MR, Greentree WK, Deschenes RJ, Linder ME. (2005) DHHC9 and GCP16 Constitute a Human Protein Fatty Acyltransferase with Specificity for H- and N-Ras. J. Biol. Chem. 280(35), 31141-31148 (SCI)
Hsieh TJ, Farh L, Huang WM, Chan NL. (2004) Structure of the topoisomerase IV C-terminal domain: A broken beta-propeller implies a role as geometry facilitator in catalysis. J Biol Chem. 279(53), 55587-55593 (SCI)

專利與研究成果：

中華民國專利：豬肺炎黴漿菌P18/P30抗原基因及其應用

校外專業服務:

1. 民國九十二年度擔任中興大學碩士第一學期碩士班學位考試委員會委員。

2. 民國九十年度聘為國立東華大學生物資訊學程籌備委員會委員。

3. 民國九十一年~九十四年度聘為國立中山大學生物科學系第一學期碩士學位考試論文考試委員。

4. 民國97年第2學期擔任國立中興大學博士班學位考試委員會委員。

5. 民國98年擔任ESERA 2009年會論文評審委員。

獲獎及榮譽：95學年度教學績優教師

主要教學科目：生物化學、生物化學實驗、應用生物資訊學、科學英文寫作、科學英文導讀

教師樊琳

Physalin B from Physalis angulata triggers the NOXA-related apoptosis pathway of human melanoma A375 cells, Chia-Chun Hsu, Yang-Chang Wu, Lynn Farh, Ying-Chi Du, Wei-Kung Tseng, Chau-Chung Wu, Fang-RongChang; Food and Chemical Toxicology, Vol 50, Issues 3–4, March–April 2012, Pages 619-624

Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide, Chyuan-Chuan Wu, Tsai-Kun Li, Lynn Farh, Li-Ying Lin, Te-Sheng Lin, Yu-Jen Yu, Tien-Jui Yen, Chia-Wang Chiang, Nei-Li Chan; Science 22 Jul 2011: Vol. 333, Issue 6041, pp. 459-462

Hsieh TJ, Yen TJ, Lin TS, Chang HT, Huang SY, Hsu CH, Farh L, Chan NL.(2010) Twisting of the DNA-binding surface by a {beta}-strand-bearing proline modulates DNA gyrase activity. Nucleic Acids Res.(SCI)

Swarthout JT, Lobo S, Farh L, Croke MR, Greentree WK, Deschenes RJ, Linder ME. (2005) DHHC9 and GCP16 Constitute a Human Protein Fatty Acyltransferase with Specificity for H- and N-Ras. J. Biol. Chem. 280(35), 31141-31148 (SCI)

Hsieh TJ, Farh L, Huang WM, Chan NL. (2004) Structure of the topoisomerase IV C-terminal domain: A broken beta-propeller implies a role as geometry facilitator in catalysis. J Biol Chem. 279(53), 55587-55593 (SCI)