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教師張雯惠

教師：張雯惠 教授

主要研究方向：

生醫感測器開發

中草藥、保健及機能性食品抗癌與功能性評估

Tel：08-766-3800 ext.：33252

E-mail：whchang@mail.nptu.edu.tw 

近五年執行計畫：

客委會(主持人)

  • 六堆客家傳統作物加值應用暨產品開發

科技部(共同主持人)

  • SU-8基板之光化學還原製備金屬奈米粒子及其應用研究(108-2221-E-006-206-)
  • 極地海洋生物與棘皮動物之二次代謝物研究(107-2320-B-153-001-)
  • 棘皮動物所含之二次代謝物及生物活性研究(106-2320-B-153-001-)
  • 膀胱癌非侵入式高精確度之表面電漿共振感測快篩技術研究(II)(106-2221-E-006-169-MY2)
  • 膀胱癌非侵入式高精確度之表面電漿共振感測快篩技術研究(105-2221-E-006 -139-)
  • 棘皮動物所含抗癌天然物探討與活性天然物誘導癌細胞凋亡分子機制研究(104-2320-B-153 -001-)
  • 利用金奈米顆粒的自組裝建置高靈敏局部表面電漿共振感測器並應用於老年黃斑部病變檢測(103-2221-E-006 -110-)
  • 研究金陣列微結構做為細胞生長基底之表面電漿行為(II)(III)(101-2221-E-006 -210 -MY2)

 

 

代表著作：

  1. Chang WH*, Yang ZY, Chong TW, Liu YY, Pan HW, Lin CH. Quantifying Cell Confluency by Plasmonic Nanodot Arrays to Achieve Cultivating Consistency. ACS Sens. 2019 Jul 26;4(7):1816-1824. doi: 10.1021/acssensors.9b00524. Epub 2019 Jun 28. PMID: 31251034
  2. Liang CC, Chang WH, Lin CH. Nanotransfer printing of plasmonic nano-pleat arrays with ultra-reduced nanocavity width using perfluoropolyether molds. J. Mater. Chem. C, 2016, 4:4491-4504
  3. Liang CC, Liao MY, Chen WY, Cheng TC, Chang WH, Lin CH. Plasmonic metallic nanostructures by direct nanoimprinting of gold nanoparticles. Opt Express. 2011 Feb 28;19(5):4768-76. doi: 10.1364/OE.19.004768. PMID: 21369308
  4. Wu JY, Chen CH, Chang WH, Chung KT, Liu YW, Lu FJ, Chen CH. Anti-Cancer Effects of Protein Extracts from Calvatia lilacina, Pleurotus ostreatus and Volvariella volvacea. Evid Based Complement Alternat Med. 2011;2011:982368. doi: 10.1093/ecam/neq057. Epub 2011 Jun 18. PMID: 21792367
  5. Ting HC, Yen CC, Chen WK, Chang WH, Chou MC, Lu FJ. Humic acid enhances the cytotoxic effects of arsenic trioxide on human cervical cancer cells. Environ Toxicol Pharmacol. 2010 Mar;29(2):117-25. doi: 10.1016/j.etap.2009.11.009. Epub 2009 Dec 3. PMID: 21787592
  6. Tsai CF, Hsu YW, Chen WK, Chang WH, Yen CC, Ho YC, Lu FJ. Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice. Food Chem Toxicol. 2009 Aug;47(8):2031-6. doi: 10.1016/j.fct.2009.05.021. Epub 2009 May 27. PMID: 19477216
  7. Chen CH, Huang TS, Wong CH, Hong CL, Tsai YH, Liang CC, Lu FJ, Chang WH*. Synergistic anti-cancer effect of baicalein and silymarin on human hepatoma HepG2 Cells. Food Chem Toxicol. 2009 Mar;47(3):638-44. doi: 10.1016/j.fct.2008.12.024. Epub 2008 Dec 25. PMID: 19150384
  8. Hsu YW, Tsai CF, Chang WH, Ho YC, Chen WK, Lu FJ. Protective effects of Dunaliella salina--a carotenoids-rich alga, against carbon tetrachloride-induced hepatotoxicity in mice. Food Chem Toxicol. 2008 Oct;46(10):3311-7. doi: 10.1016/j.fct.2008.07.027. Epub 2008 Aug 12. PMID: 18761048
  9. Hseu YC, Chang WH, Chen CS, Liao JW, Huang CJ, Lu FJ, Chia YC, Hsu HK, Wu JJ, Yang HL. Antioxidant activities of Toona Sinensis leaves extracts using different antioxidant models. Food Chem Toxicol. 2008 Jan;46(1):105-14. Epub 2007 Jul 16. PMID: 17703862
  10. Yang HL, Chang WH, Chia YC, Huang CJ, Lu FJ, Hsu HK, Hseu YC. Toona sinensis extracts induces apoptosis via reactive oxygen species in human premyelocytic leukemia cells. Food Chem Toxicol. 2006 Dec;44(12):1978-88. Epub 2006 Jul 18. PMID: 16945458
  11. Liu GY, Liao YF, Hsu PC, Chang WH, Hsieh MC, Lin CY, Hour TC, Kao MC, Tsay GJ, Hung HC. Antizyme, a natural ornithine decarboxylase inhibitor, induces apoptosis of haematopoietic cells through mitochondrial membrane depolarization and caspases' cascade. Apoptosis. 2006 Oct;11(10):1773-88. PMID: 16927018
  12. Hsu PC, Hour TC, Liao YF, Hung YC, Liu CC, Chang WH, Kao MC, Tsay GJ, Hung HC, Liu GY. Increasing ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: crosstalk between ODC and BCL-2. Apoptosis. 2006 Mar;11(3):389-99. PMID: 16520895
  13. Liu GY, Liao YF, Chang WH, Liu CC, Hsieh MC, Hsu PC, Tsay GJ, Hung HC. Overexpression of peptidylarginine deiminase IV features in apoptosis of haematopoietic cells. Apoptosis. 2006 Feb;11(2):183-96. PMID: 16502257
  14. Yang HL, Chen CS, Chang WH, Lu FJ, Lai YC, Chen CC, Hseu TH, Kuo CT, Hseu YC. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorata. Cancer Lett. 2006 Jan 18;231(2):215-27. PMID: 16399223
  15. Hseu YC, Wu FY, Wu JJ, Chen JY, Chang WH, Lu FJ, Lai YC, Yang HL. Anti-inflammatory potential of Antrodia Camphorata through inhibition of iNOS, COX-2 and cytokines via the NF-kappaB pathway. Int Immunopharmacol. 2005 Dec;5(13-14):1914-25. Epub 2005 Jul 18. PMID: 16275626
  16. Liao YF, Hung YC, Chang WH, Tsay GJ, Hour TC, Hung HC, Liu GY. The PKC delta inhibitor, rottlerin, induces apoptosis of haematopoietic cell lines through mitochondrial membrane depolarization and caspases' cascade. Life Sci. 2005 Jun 24;77(6):707-19. PMID: 15922001
  17. Liu GY, Hung YC, Hsu PC, Liao YF, Chang WH, Tsay GJ, Hung HC. Ornithine decarboxylase prevents tumor necrosis factor alpha-induced apoptosis by decreasing intracellular reactive oxygen species. Apoptosis. 2005 May;10(3):569-81. PMID: 15909119
  18. Liu JJ, Huang TS, Hsu ML, Chen CC, Lin WS, Lu FJ, Chang WH. Antitumor effects of the partially purified polysaccharides from Antrodia camphorata and the mechanism of its action. Toxicol Appl Pharmacol. 2004 Dec 1;201(2):186-93. PMID: 15541758
  19. Chang WH, Liu JJ, Chen CH, Huang TS, Lu FJ. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by fermented soy milk. Nutr Cancer. 2002;43(2):214-26. PMID: 12588701
  20. Chang WH, Chen CH, Gau RJ, Lin CC, Tsai CL, Tsai K, Lu FJ. Effect of baicalein on apoptosis of the human Hep G2 cell line was induced by mitochondrial dysfunction. Planta Med. 2002 Apr;68(4):302-6. PMID: 11988851
  21. Chang WH, Chen CH, Lu FJ. Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines. Planta Med. 2002 Feb;68(2):128-32. PMID: 11859462
  22. Tsai WY, Chang WH, Chen CH, Lu FJ. Enhancing effect of patented whey protein isolate (Immunocal) on cytotoxicity of an anticancer drug. Nutr Cancer. 2000;38(2):200-8. PMID: 11525598

專利與研究成果：

 

技術轉移：中藥方劑小柴胡湯之成分誘導人類肝癌細胞計劃性死亡之機制探討

校外專業服務:

1.台灣自由基學會 理事 (2007. 03 ～2010. 03)

2.台灣自由基學會 監事(2010. 03 ～)

3. Reviewer for Scientific Periodicals (SCI)- Cancer letters (2010. 03 ~)

4.國立中興大學博士學位考試委員

5.國立交通大學碩士學位考試委員

6.國立台灣大學碩士學位考試委員

7.國立成功大學碩士學位考試委員

 

獲獎及榮譽：

  • 獲傅爾布萊特－台塑企業獎助學金(資深學者)赴耶魯大學訪問研究
  • 於高雄應用科技大學舉辦之『教育部補助技專校院發展學校重點特色計畫--98年專題競賽暨成果發表』人工器官組壁報論文第一名

主要教學科目：普通生物學、生物化學、免疫學、腫瘤生物學