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天然藥物化學實驗室

 

國立屏東大學

應用化學系

教師

李佳穎   

職級

副教授

主要研究方向

中草藥天然物萃取分離、活性成分分析、藥理活性篩選、分析方法開發、品質管制、精油萃取技術、製程改善研究

學歷

成功大學化學博士

經歷
  1. 國立成功大學化學系博士後研究(2002. 01~2008. 01)
  2. 高雄醫學大學香粧品學系兼任講師(2007. 02~2007. 07)
  3. 大仁科技大學製藥科技研究所兼任講師(2007.08~2008.01)
  4. 國立屏東教育大學應用化學暨生命科學系專案助理教授(2008.02~2010.01)
  5. 國立屏東教育大學化學生物系專任助理教授(2010.02～2022.01))
  6. 國立屏東教育大學研究發展處綜合企劃組組長(2010.08~2013.07)
  7. 國立屏東大學應用化學系專任副教授(2022.02~)

近年執行及參與計畫
  1. 生理活性天然物之探討 (國科會NSC 98-2320-B-153-001-MY3，主持人，98/08/01~101/07/31)
  2. 玉蘭花高值化功能性附產品開發 (經濟部PS099170232，主持人，99/07/01~99/12/31)
  3. 玉蘭花香味形象建立與香味圖譜分析 (楓荷生物科技股份有限公司，主持人，100/09/01~101/07/31)
  4. 野薑花萃取物產品應用研發計畫 (楓荷生物科技股份有限公司，主持人，101/05/01~101/10/30)
  5. 地方特色農業加值開發計畫 (經濟部PS101150719，主持人，101/05/01~101/10/30)
  6. 新機能性保養品原料開發(國立屏東教育大學，主持人，101/01/01~101/12/31)
  7. 中藥降血糖活性成分研究(國立屏東教育大學，主持人，102/06/01~102/12/31)
  8. 蘭花香氛產品穩定性測試研發計畫(蘭卉生物科技股份有限公司，主持人，102/08/01~103/05/31)
  9. 蝴蝶蘭葉部活性成分研究(蘭卉生物科技股份有限公司，主持人，103/08/01~104/07/31，)
  10. 番木瓜機能性保養品技術商品化(教育部區域產學合作中心，主持人，103/09/01~103/11/30)
  11. 中藥精油替代防腐系統研發(國立屏東大學，主持人，104/04/01~104/12/31)
  12. 產品香氛之解構與重建(蘭卉生物科技股份有限公司，主持人，104/08/01~105/07/31，)
  13. 降血糖暨抗氧化功能性原料開發(國立屏東大學，主持人，105/01/01~105/12/31)
  14. 鑑別最佳化蘭胚萃取方式開發(蘭卉生物科技股份有限公司，主持人，105/01/01~105/12/31)
  15. 香蕉花活性暨品質管制標準建立開發計畫(金利食安科技股份有限公司，主持人，105/08/01~106/07/31)
  16. 美白暨抗氧化功能性原料開發(國立屏東大學，主持人，106/01/01~106/12/31)
  17. 蜂場高值化附產品開發計畫(金標養蜂場，主持人，106/06/01~107/05/31)
  18. 農業廢棄物加值計畫(國立屏東大學，主持人，107/01/01~107/12/31)
  19. 大學社會責任實踐計畫-讓生命不同凡「想」-屏東身心障礙成人服務機構支持網絡(教育部，共同主持人，107/01/01~108/12/31)
  20. 補助大學校院發展客家學術機構計畫─靚靚六堆-六堆客家傳統作物加值應用暨產品開發(客委會，共同主持人，107/01/01~107/11/30)
  21. 107年度學界協助中小企業科技關懷跨域整合計畫-農村再生2.0跨域整合加值計畫(經濟部技術處，共同主持人，107/05/01~107/10/31)
  22. 蜂毒活性肽之量產製程與品質管制研究(池上樂蜂場，主持人，107/09/01~108/07/31)
  23. 可可果莢資源再開發計畫(國立屏東大學，主持人，108/01/01~108/12/31)
  24. 讓生命不同凡「想」-屏東身心障礙成人服務友善環境的建置(教育部，協同主持人，109/01/01~109/12/31)
  25. 提升麴酸美白功效之複合物開發(國立屏東大學，主持人，109/03/01~109/12/31)
  26. 綠金產業生態材料加值開發計畫(國立屏東大學，主持人，109/06/01~109/12/31)
  27. 109年度學界協助中小企業科技關懷計畫-智能製造加工產業技術與生產效能提升計畫(經濟部技術處，共同主持人，109/08/01~109/11/30)
  28. 抗癌活性中草藥之篩選研究(博怡蘭科技有限公司，主持人，109/08/01~110/07/31)
  29. 蝴蝶蘭種子組織培養與共生菌培養之脂質代謝調控之研究(科技部，MOST 109-2635-B-006 -005 -，共同主持人，109/08/01~110/07/31)
  30. 屏縣中小學生活化學實作推廣 (科技部，MOST 109-2635-H-153-001-，共同主持人，109/08/01~110/07/31)
  31. 讓生命不同凡「想」-屏東身心障礙成人服務友善環境的建置(教育部，協同主持人，110/01/01~110/12/31)
  32. 植物抗逆境菌種篩選及其應用開發研究(國立屏東大學，總主持人，110/01/01~110/11/30)
  33. 糖果蘭活性成分及妝品運用開發(芸蘭國際股份有限公司，主持人，110/08/01~111/07/31)
  34. 讓生命不同凡「想」-屏東身心障礙成人服務友善環境的建置(教育部，協同主持人，111/01/01~111/12/31)
  35. 蘭花種子萌發與生存適應：蘭花種子如何面對沒有胚乳--蘭花種子萌發前和真菌共生之交互作用(1/3)(國科會111-2313-B-006-003-，共同主持人，111/08/01~112/07/31)
  36. 利用生物轉化技術提升木瓜廢棄物所含類黃酮之萃取效率 (國立屏東大學 循環經濟創新應用計畫，主持人，111/10/07-111/12/31)
  37. 以誘導劑提升香草精油品質及產量之研究(國立屏東大學，主持人，112/01/18~112/11/30)
  38. 糖果蘭活性成分之經皮穿透效益研究(芸蘭國際股份有限公司，主持人，112/08/01~113/07/31)

研究成果

期刊論文

  1. Chan, Y. Y.; Leu, Y, L.; Lin, F. W.; Li, Chia-Ying; Wu, Y. C.; et. al.; “A secoiridoid and other constituents of Gonocaryum calleryanum”; Phytochemistry; 1998; 47; 1073-1077. SCI
  2. Wu, T. S.*; Leu, Y. L.; Chan, Y. Y.; Lin, F. W.; Li, Chia-Ying; et. al.; “Severibuxine, a new quinolin-2,4-dione and other constituents from Severinia buxifolia”; Phytochemistry; 1998; 49; 1467-1470. SCI
  3. Wu, T. S.*; Li, Chia-Ying; Leu, Y. L.; Hu, C. Q.; “Limonoids and alkaloids of the root bark of Dictamnus angustifolius”; Phytochemistry; 1999; 50; 509-512. SCI
  4. Wu, T. S.*; Chan, Y. Y.; Leu, Y. L.; Wu, P. L.; Li, Chia-Ying; et. al.; “Four aristolochic acid esters of rearranged ent-elemane sesquiterpenes from Aristolochia heterophylla”; J. Nat. Prod.; 1999; 62; 348-351. SCI
  5. Wu, T. S.*; Kao, M. S.; Wu, P. L.; Lin, F. W.; Shi, L. S.; Li, Chia-Ying; “The bakkenolides from the root of Petasites formosanus and their cytotoxicity”; Chem. Pharm. Bull.; 1999; 47; 375-382. SCI
  6. Wu, T. S.*; Tsang, Z. J.; Wu, P. L.; Lin, F. W.; Li, Chia-Ying; et. al.; “New constituents and antiplatelet aggregation and anti-HIV principles of Artemisia capillaries”; Biorg. Med. Chem.; 2001; 9; 77-83. SCI
  7. Kuo, P. C.; Chiu, C. C.; Shi, L. S.; Li, Chia-Ying; Wu, S. J.; et. al.; “Non-alkaloidal constituents from the stem of Ficus septica”; J. Chin. Chem. Soc.; 2002; 49; 113-116. SCI
  8. Li, Chia-Ying; Wu, T. S.*; “Constituents of the pollen of Crocus sativus L. and their tyrosinase inhibitory activity”; Chem. Pharm. Bull.; 2002; 50; 1305-1309. SCI
  9. Li, Chia-Ying; Wu, T. S.*; “Constituents of the stigmas of Crocus sativus and their tyrosinase inhibitory activity”; J. Nat. Prod.; 2002; 65; 1452-1456. SCI
  10. Wu, T. S.*; Hsu, M. Y.; Damu, A. G.; Kuo, P. C.; Su, C. R.; Li, Chia-Ying; et. al.; “Constituents of Leaves of Phellodendron chinense var. glabriusculum”; Heterocycles; 2003; 60; 397-404. SCI
  11. Lin, C. H.; Li, Chia-Ying; Kuoh, C. S; Wu, T. S.*; “Constituents of the leaves of Petasites formosanus and their antioxidative activity.”; Heterocycles; 2003; 60; 1881-1889. SCI
  12. Wu, T. S.*; Hsu, M. Y.; Kuo, P. C.; Sreenivasulu, B.; Damu, A. G.; Su, C. R.; Li, Chia-Ying; et. al.; “Constituents from the Leaves of Phellodendron amurense var. wilsonii and Their Bioactivity”; J. Nat. Prod.; 2003; 66; 1207-1211. SCI
  13. Jou, J. H.; Li, Chia-Ying; Wu, T. S.; “The analysis of the analogues of aristolochic acid and aristololactam in the plant of Aristolochia genus by HPLC.”; J. Food. Drug Anal.; 2004; 12; 40-45. SCI
  14. Kuo, P. C.; Hsu, M. Y.; Damu, A. G.; Su, C. R.; Li, Chia-Ying; et. al.; “Flavonoids and coumarins from leaves of Phellodendron chinense”; Planta Med.; 2004; 70; 183-185. SCI
  15. Li, Chia-Ying; Lee, E. J.; Wu, T. S.; “Antityrosinase principles and constituents of the petals of Crocus sativus.”; J. Nat. Prod.; 2004; 67; 437-440. SCI
  16. Li, Chia-Ying; Lin, C. H.; Wu, C. C.; Wu, T. S.; “Efficient 1H NMR Method for Improved Quality Control Analyses of Ginkgo Constituents.”; J. Agric. Food Chem.; 2004; 52; 3721-3725. SCI
  17. Lin, C. H.; Li, Chia-Ying; and Wu, T. S.; “A Novel Phenylpropenoyl Sulfonic Acid and a New Chlorophyll from the Leaves of Petasites formosanus Kitamura”; Chem. Pharm. Bull.; 2004; 52; 1151-1152. SCI
  18. Li, Chia-Ying; Lin, C. H.; Wu, T. S.; “Quantitative Analysis of Camptothecin Derivatives in Nothapodytes foetida Using 1H NMR Method.”; Chem. Pharm. Bull.; 2005; 53; 347-349. SCI
  19. Damu, A. G.; Kuo, P. C.; Li, Chia-Ying; Shi, L. S.; Kuoh, C. S.; et. al.; “Phenanthroindolizidine alkaloids from the stem of Ficus septica.”; J. Nat. Prod.; 2005; 68; 1071-1075. SCI
  20. Chih-Yang Chiu, Chia-Ying Li, Chao-Chen Chiu, Shih-Pin Hsu, et. al.; “Constituents of Leaves of Phellodendron japonicum Maxim. and Their Antioxidant Activity.”; Chem. Pharm. Bull.; 2005; 53; 1118-1121. SCI
  21. Hsiu-Hui Chan, Chia-Ying Li, A. G. Damu, and Tian-Shung Wu; “Anthraquinones from Ophiorrhiza hayatana Ohwi.”; Chem. Pharm. Bull.; 2005; 53; 1232-1235. SCI
  22. Chia-Ying Li, Tahsin J. Chow, and Tian-Shung Wu; “The Epimerization of Sesamin and Asarinin”; J. Nat. Prod.; 2005; 68; 1622-1624. SCI
  23. Li, Chia-Ying; Lu, H. J.; Lin, C. H.; Wu, T. S.; “A Rapid and Simple Determination of Protoberberine Alkaloids in Cortex Phellodendri by 1H NMR and Its Application for Quality Control of Commercial Traditional Chinese Medicine Prescriptions.”; J. Pharm. Biomed. Anal.; 2006; 40; 173-178. SCI
  24. Li, Chia-Ying; Chiu, C. H.; Huang H. S.; Lin, C. H.; Wu, T. S.; “High performance liquid chromatographic method for simultaneous quantification of eight major biologically active ingredients of in “Da-Chai-Hu-Tang” Preparation.”; Biomed. Chromatogr.; 2006; 20; 305-308. SCI
  25. E-Jian Lee, Tian-Shung Wu, Guan-Liang Chang, Chia-Ying Li, Tsung-Ying Chen, et. al.; “Delayed Treatment with Nicotinamide Inhibits Brain Energy Depletion,Improves Cerebral Microperfusion, Reduces Brain Infarct Volume, but does not Alter Neurobehavioral Outcome Following Permanent Focal Cerebral Ischemia in Sprague Dawley Rats.”; Current Neurovascular Research; 2006; 3; 203-213. SCI
  26. C. H. Leu; Chia-Ying Li; Yao, X.; and Tian-Shung Wu; “Constituents from the Leaves of Phellodendron amurense and Their Antioxidant Activity.”; Chem. Pharm. Bull.; 2006; 54; 1308-1311. SCI
  27. Mo-Chi Cheng, Chia-Ying Li, Han-Chieh Ko, Feng-Nien Ko, et. al.; “Antidepressant principles from the Roots of Polygala tenuifolia”; J. Nat. Prod.; 2006; 69; 1305-1309. SCI
  28. Chia-Ying Li, Tian-Shung Wu; “A Brief Review on Chemical Constituents and Their Bioactivity from Crocus sativus L.”; Chin. J. Nat. Med.; 2006; 11; 55-59.
  29. Chia-Ying Li, Wei-Jern Tsai, Amooru Gangaiah Damu, E-Jian Lee, Tian-Shung Wu*, Nguyen Xuan Dung, et. al.; “Isolation and Identification of Antiplatelet Aggregatory Principles from the Leaves of Piper lolot”; J. Agric. Food Chem.; 2007; 55; 9436-9442. SCI
  30. Yu-Yun Hsiao, Mei-Fen Jeng, Wen-Chieh Tsai, Yu-Chen Chuang, Chia-Ying Li, et. al.; “A novel homodimeric geranyl diphosphate synthase from the orchid Phalaenopsis bellina lacking a DD(X)2–4D motif”; The Plant Journal; 2008; 55; 719-733. SCI
  31. Chuan-Chung Tsao, Yuh-Chiang Shen,Chung-Ren Su, Chia-Ying Li, et. al.; “New Diterpenoids and the bioactivity of Erythrophleum fordii”; Bioorg. Med. Chem.; 2008; 16; 9867-9870. SCI
  32. Chia-Ying Li, Hong-Xi Xu, Quan-Bin Han, Tian-Shung Wu; “Quality assessment of Radix Codonopsis by quantitative nuclear magnetic resonance”; J. Chromatogr. A; 2009; 1216; 2124-2129. SCI
  33. Chia-Ying Li, Sung-I Tsai, Amooru G. Damu, Chung-Ren Su, Tian-Shung Wu; “A Rapid and Simple Determination of Protoberberine Alkaloids in Rhizoma Coptidis by 1H NMR and Its Application for Quality Control of Commercial Prescriptions”; J. Pharm. Biomed. Anal.; 2009; 49; 1272-1276. SCI
  34. A. G. Damu, P. C. Kuo, L. S. Shi, Chia-Ying Li, and Tian-Shung Wu; “Cytotoxic Phenanthroindolizidine Alkaloids from the Roots of Ficus septica”; Planta Med.; 2009; 75; 1152-1156. SCI
  35. Te-Ling Lu, Chien-Kuo Han, Yuan-Shiun Chang, Te-Jung Lu, Hui-Chi Huang, Bo-Ying Bao, Hsing-Yu Wu, Chieh-Hung Huang, Chia-Yen Li and Tian-Shung Wu, Denbinobin, a Phenanthrene from Dendrobium nobile, Impairs Prostate Cancer Migration by Inhibiting Rac1 Activity. The American Journal of Chinese Medicine, 2014, 42, 1539–1554.  SCI
  36. Yen-Chun Huang, Hui-Chun Lee, Yun-Lian Lin, Chia-Ying Li, Chia-Fen Tsai, Hwei-Fang Cheng, Separation and identification of a novel tadalafil analogue adulterant in a dietary supplement. Food Additives & Contaminants: Part A; 2015; 21, 51.  03 Dec 2015 online. SCI
  37. Patathananone S, Daduang J, Koraneekij A, Li Chia-Ying. Tyrosinase Inhibitory Effect, Antioxidant and Anticancer Activities of Bioactive Compounds in Ripe Hog Plum (Spondias Pinnata) Fruit Extracts. Orient J Chem 2019; 35 (3). 916-926.  Article Published online: 12 Jun 2019 ESCI
  38. Yi-Jui Chen, Wen-Huei Chang, Chia-Ying Li, Yi-Chun Chiu, Chih-Chia Huang, Chun-Hung Lin, Direct synthesis of monolayer gold nanoparticles on epoxy based photoresist by photoreduction and application to surface-enhanced Raman sensing. Materials and Design 2021, 197, 109211. SCI
  39. Hsin-Yi Hung, Shih-Min Lin, Chia-Ying Li, Sio-Hong Lam, Yu-Yi Chan, Meei-Jen Liou, Po-Chuen Shieh, Fu-An Chen, Ping-Chung Kuo, Tian-Shung Wu, A Rapid and Feasible 1H-NMR Quantification Method of Ephedrine Alkaloids in Ephedra Herbal Preparations. Molecules 2021, 26, 1599. SCI
  40. Yi-Ying Wu, Chia-Ching Hsieh, Chia-Ying Li, Wen-Huei Chang, Jih-Jung Chen, Kuei-Hung Lai, Zhi-Hong Wen and Hsu-Ming Chung. Natural Cembrane Diterpenoids From the Soft Coral Sinularia querciformis. Natural Product Communications 2021, 16(11), 1-5. SCI
  41. Chia-Ying Li, Constituents of the Flower of Maxillaria tenuifolia and Their Anti-Diabetic Activity. Records of Natural Products 2022, 16 (3), 247-252. Available online: August 18, 2021. May 2022 SCI.
  42. Hsiang-Chia Lu, Sio-Hong Lam, Di-Yang Zhang, Yu-Yun Hsiao, Bai-Jun Li, Shan-Ce Niu, Chia-Ying Li, Si-Ren Lan, Wen-Chieh Tsai, and Zhong-Jian Liu, R2R3-MYB genes coordinate conical cell development and cuticular wax biosynthesis in Phalaenopsis aphrodite. PLANT PHYSIOLOGY 2022, 188, 318-331. Available online: September 02, 2021. January 2022 SCI.
  43. Ming-He Li, Ke-Wei Liu, Zhen Li, Hsiang-Chia Lu, Qin-Liang Ye, Diyang Zhang, Jie-Yu Wang, Yu-Feng Li, Zhi-Ming Zhong, Xuedie Liu, Xia Yu, Ding-Kun Liu, Xiong-De Tu, Bin Liu, Yang Hao, Xing-Yu Liao, Yu-Ting Jiang, Wei-Hong Sun, Jinliao Chen, Yan-Qiong Chen, Ye Ai, Jun-Wen Zhai, Sha-Sha Wu, Zhuang Zhou, Yu-Yun Hsiao, Wan-Lin Wu, You-Yi Chen, Yu-Fu Lin, Jui-Ling Hsu, Chia-Ying Li, Zhi-Wen Wang, Xiang Zhao, Wen-Ying Zhong, Xiao-Kai Ma, Liang Ma, Jie Huang, Gui-Zhen Chen, Ming-Zhong Huang, Laiqiang Huang, Dong-Hui Peng, Yi-Bo Luo, Shuang-Quan Zou, Shi-Pin Chen, Siren Lan, Wen-Chieh Tsai, Yves Van de Peer & Zhong-Jian Liu, Genomes of leafy and leafless Platanthera orchids illuminate the evolution of mycoheterotrophy. Nature Plants 2022, 8, 373-388. April 2022 SCI
  44. Cheng-Huan Peng, Wen-Ying Lin, Chia-Ying Li, Kameshwara Kumar Dharini, Chih-Yu Chang, Jo-Ting Hong, Ming-Der Lin, Gu Sui Bu (Drynaria fortunei J. Sm.) antagonizes glucocorticoid-induced mineralization reduction in zebrafish larvae by modulating the activity of osteoblasts and osteoclasts. Journal of Ethnopharmacology 2022, 297, 115565. 28 October 2022 SCI.
  45. Zong-You Li, Chia-Ying Li, Kuei-Hung Lai, Mei-Yi Liao,Wei-Hsien Wang, and Hsu-Ming Chung, Chemical constituents from the octocoral Lobophytum sarcophytoides. Chemistry of Natural Compounds, 2022, 58(6), 1167-1169. November, 2022. SCI.
  46. Tsun-Ren Chen, Yi-Sheng Chen, Chia-Ying Li, Yen-Hsing Lin and Yu-Tung Chen, Spontaneous Release of Metalloradicals and Coordinatively Unsaturated Species in Asymmetric Iridium Dimers to Promote C-N Bond Formation. Inorganics, 2022, 10, 237. 2 December 2022 SCI
  47. Liang Ma, Ke-Wei Liu, Zhen Li, Yu-Yun Hsiao, Yiying Qi, Tao Fu, Guang-Da Tang, Diyang Zhang, Wei-Hong Sun, Ding-Kun Liu, Yuanyuan Li, Gui-Zhen Chen, Xue-Die Liu, Xing-Yu Liao, Yu-Ting Jiang, XiaYu, Yang Hao, Jie Huang, Xue-Wei Zhao, Shijie Ke, You-Yi Chen, Wan-LinWu, Jui-Ling Hsu, Yu-Fu Lin, Ming-Der Huang, Chia-Ying Li, Laiqiang Huang, Zhi-Wen Wang, Xiang Zhao, Wen-Ying Zhong, Dong-Hui Peng, Sagheer Ahmad, Siren Lan , Ji-Sen Zhang , Wen-Chieh Tsai, Yves Van de Peer & Zhong-Jian Liu, Diploid and tetraploid genomes of Acorus and the evolution of monocots. Nature Communications 2023, 14:3661. June 2023. SCI
  48. Te-An Kung, Lo-Yun Chen, Chia-Ying Li, Bo-Rong Peng, Tsong-Long Hwang, Ping-Jyun Sung, Kuei-Hung Lai, Hsu-Ming Chung, Anti-inflammatory cembrane-based diterpenoids isolated from the octocoral Sinularia querciformis. Phytochemistry Letters 2023. 55, 12-16. June 2023. SCI
  49. Yi-Sheng Chen, Siang-Yu Chiu, Chia-Ying Li, Tsun-Ren Chen and Jhy-Der Chen, Ligand effect of cyclometallated iridium(III) complexes on N-alkylation of amines in hydrogen borrowing reactions. RSC Adv., 2023, 13, 31948-31961. October 2023. SCI
  50. Chia-Ling Hung, Li-Chieh Huang, Kun-Yauh Shih, Kuei-Hung Lai, Bo-Rong Peng, Tsong-Long Hwang, Su-Ying Chien, Chia-Ying Li*, Hsu-Ming Chung*. A new sterol from the Formosan soft coral Lobophytum durum.  Journal of Molecular Structure 2024. 1296, 136790. 15 January 2024. SCI

主要教學科目

天然物化學、藥物化學、有機光譜學、有機光譜特論、生技化妝品、儀器分析、儀分實驗

教授課程與本系整體課程之關連

本學系以培養學生具備化學與生命科學領域之整合性知能為教育目標之一。而中草藥產業是高附加價值、結合化學與生命科學的跨領域科技產業，近年來政府亦大力推動生技製藥及中草藥科技化產業之發展。有鑑於此，教授之課程包含天然物化學、藥物化學等基礎與進階課程，強調中草藥或其他天然材料的研究方法及對各種天然產物的深入了解，並介紹藥物作用機轉與新藥設計策略，期使學生對製藥產業及中草藥科技有清楚的認識。儀器分析及實驗、有機光譜學及特論則是研究過程中不可或缺的一項重要課目，藉由此課程的講授，期能訓練學生在各項光譜分析儀器的運用能有更深一層的體認，以及能掌握藥物開發過程中可能運用到的實驗技能。生技化妝品則是近年的新興產業領域，藉由課程的進行期望除使學生了解未來的研究應用發展方向之外，亦可建構學生在未來面對創新產業有統概性的理解與體認。

研究發展方向

中藥歷經數千年的人體實驗，對新藥開發提供了一條最好的捷徑。往昔受限於各種實驗技術與儀器，故很少以現代醫學方法加以評估其藥效，也因此常被譏為不科學。近年來各種先進的儀器和新分析材料的出現與新藥理篩選方法的建立，以及全世界崇尚自然療法的蓬勃發展，此為中藥發展之最佳契機。天然物中草藥的活性成分分離是本研究室的研究重點。針對一些具有生理活性的天然植物或微生物來源進行活性成分分離與結構鑑定研究，除了可以發現新化合物之外，所分離得到的成分將可作為進行活性測試的成分來源，而具有不錯的生理活性之成分，可嘗試其全合成或半合成。甚至可以進一步對具有生理活性之成分進行衍生化反應，以嘗試合成得到活性更高之化合物，以使藥物資源的開發與利用可以獲得最高的效益。而研究題材評估其安全性，若具有顯著活性而無毒性，亦可開發成為保健食品。另外，隨著國際間對中草藥的重視，中藥科學化已是一個相當重要的課題，如何能有效定性定量來源藥材之活性成分、真偽藥之鑑別，對中藥科學化具有決定性的影響。因此中草藥品質管制及分析方法開發也將是本實驗室的另一重點項目。
總括來說，本實驗室的研究重點如下：

  1. 具生理活性天然物活性成分分離研究
  2. 抗氧化、美白、調節血糖、抗過敏、抗癌、神經保護..等活性成分篩選
  3. 中草藥品質管制方法開發
  4. 中草藥化妝保養品研發
  5. 芳香精油萃取技術
  6. 農作物附加價值開發

專利或研究成果應用情形

專利

  1. 吳天賞, 李佳穎, 王玉杯, 一種快速定性與定量分析銀杏製品中所含之活性成分的方法, 中華民國專利 I266874, 南光製藥, 20061121
  2. 王慧珍, 李佳穎, 玉蘭花定香複合物之製造方法,中華民國專利I437091, 楓荷生物科技, 20140511. 「玉蘭花定香複合物之製造方法」榮獲2012年第37屆克羅埃西亞INOVA國際發明展金牌、2012年第八屆台北國際發明暨技術交易展IIPNF國際知識產權交流會「領先創新獎」和IWIA波蘭特別獎、AIA亞洲發明協會金牌、Semi-Grand Award獎。
  3. 蔡文杰, 蕭郁芸, 陳文輝, 陳虹樺, 蕭永振, 蕭郁萍, 蕭郁韋, 李佳穎, 許瑞鈴, 吳宛霖, 林家瑜, 含保濕成份之蘭花種子萃取物及其添加產品, 中華民國專利I642449, 蘭卉生物科技股份有限公司, 20181201.
  4. 蔡文杰, 梁傑剴, 吳宛霖, 蕭郁芸, 李佳穎, 林玉麒, 陳文輝, 蘭花種子之萃取物及其添加產品, 中華民國專利I645847, 芸蘭國際股份有限公司, 20190101.
  5. 蔡文杰, 蕭郁芸, 陳文輝, 蕭永振, 蕭郁萍, 蕭郁韋, 李佳穎, 許瑞鈴, 吳宛霖, 林家瑜, 具蘭花種子萃取物之產品組合體, 中華民國新型專利 M632513, 蘭卉生物科技股份有限公司, 20221001.